Comparison between hypoglycemic effects of Cuminum cyminum L. seeds and glibenclamide in diabetic rats

The purpose of this research was to compare the anti-hyperglycemic effect of Cuminum cyminum L. and glibenclamide, a known antidiabetic drug, in diabetic rats. After collection and taxonomic identification of plant, alcoholic extract of seeds prepared suxhlet apparatus respectively. The animals were made diabetic by using streptozotocin (70 mg/kg, i.p.). The diabetic rats were administrated intraperitoneally with the extract or glibenclamide (600 mg/kg). Blood samples were obtained before administration and 1.5, 3 and 5 h after administration of extract and distilled water as a control groups. Then, the blood glucose was measured by the enzymatic method of glucose oxidize. The results show that the antidiabetic effect of Cuminum cyminum was more effective than glibenclamide. It is concluded that this plant must be considered as an excellent candidate for future studies on diabetes mellitus. In addition, further comprehensive pharmacological investigations, including experimental chronic studies, should be carried out.